2,2-dimethyl-propanedioic acid dimethyl ester

2,2-dimethyl-propanedioic acid dimethyl ester - Names and Identifiers

Name	2,2-dimethyl-propanedioic acid dimethyl ester
Synonyms	Dimethyl dimethylmalonate DIMETHYL 2,2-DIMETHYL-MALONATE dimethyl dimethylpropanedioate dimethyl 2,2-dimethylpropanedioate Dimethyl 2.2-dimethyl propanedioate Dimethyl 2,2-dimethyl propanedioate 2,2-Dimethyl-malonic acid dimethyl ester Dimethylpropanedioic acid dimethyl ester 2,2-DIMETHYL-MALONIC ACID DIMETHYL ESTER Propanedioic acid, dimethyl-, dimethyl ester 2,2-dimethyl-propanedioic acid dimethyl ester 2,2-dimethyl-propanedioic acid dimethyl ester Propanedioic acid, 2,2-dimethyl-, 1,3-dimethyl ester
CAS	6065-54-9
EINECS	1312995-182-4
InChI	InChI=1/C7H12O4/c1-7(2,5(8)10-3)6(9)11-4/h1-4H3

2,2-dimethyl-propanedioic acid dimethyl ester - Physico-chemical Properties

Molecular Formula	C7H12O4
Molar Mass	160.17
Density	1.0675 g/cm3
Boling Point	53.5-54.5 °C(Press: 6 Torr)
Flash Point	71.6°C
Vapor Presure	1.6mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.416

2,2-dimethyl-propanedioic acid dimethyl ester - Reference Information

Use

dimethyl 2, 2-dimethylmalonate is a versatile organic compound. Commonly used in pharmaceutical pipemidic acid intermediates and Fragrance Intermediates, pesticide intermediates synthesis of raw materials.

preparation

synthesis method of dimethyl 2, 2-dimethylmalonate: a synthesis method of dimethyl 2, 2-dimethylmalonate: weigh 104.2g of 2, 2-dimethyl-1, 3-propanediol and 0.2g of Phosphotungstic acid as catalyst, add to 340g of 50% hydrogen peroxide solution in batch with constant stirring, oxidize it to 2, the crude solution of 2, 2-dimethylmalonic acid had a molar ratio of 2, 2-dimethyl-1, 3-propanediol to hydrogen peroxide of 1:5. Concentrated and acidified, and after cooling, crystals of 2, 2-dimethylmalonic acid were obtained. The crystals were filtered with suction and recrystallized with deionized water to obtain a pure product of 2, 2-dimethylmalonic acid with a yield of 86%. Then, sodium bisulfate monohydrate was used as a catalyst, and the amount added was 10% of the mass of 2, 2-dimethylmalonic acid. 2, 2-dimethylmalonic acid was esterified with methanol, and cyclohexane was used as a water-carrying agent. Methanol and 2, The molar ratio of 2-dimethylmalonic acid is 6:1, the reaction temperature is 70-75 ° C., and the reaction time is 2-4 hours. After the reaction, the cyclohexane and methanol were distilled off, and the liquid was applied. The crude product, dimethyl 2, 2-dimethylmalonate, was washed with water, separated, dried with anhydrous magnesium sulfate, and distilled under reduced pressure with an oil pump, the 106-110 ° C. Fractions were collected to obtain dimethyl 2, 2-dimethylmalonate in a yield of 96%. The purity was 99.96%.

Last Update：2024-04-10 22:29:15